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This is distinct from the common liability to addiction (CLA) model, which proposes that shared genetic, environmental, and psychosocial vulnerability predisposes individuals to all substance use simultaneously, with initiation sequence driven by drug availability and social context rather than neurobiological priming

Major trends in the forecast period include product reformulation with reduced harm focus, expansion of modern smokeless tobacco formats, growing use of portion-controlled products, increased emphasis on compliance and traceability, packaging innovation for freshness

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